Chloroform metabolism
WebApr 7, 2024 · Inhibiting energy metabolism of cancer cells is an effective way to treat cancer but remains a great challenge. Herein, electrostimulation (ES) is applied to effectively suppress energy metabolism of cancer cells to induce rapid cell death, and deeply reveal the underlying mechanisms at the molecular and nanomechanical levels by combined … WebBoth oxidative and reductive pathways of chloroform metabolism have been described, although data in vivo are limited. Carbon dioxide is the major metabolite of chloroform generated by the oxidative pathway of metabolism in vivo. The oxidative pathway also generates reactive metabolites, ...
Chloroform metabolism
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Webof metabolism are the liver and kidneys. Excretion of chloroform occurs primarily via the lungs, either as unchanged chloroform or as carbon dioxide (ATSDR, 1989). Target … WebThe methylation status of the myc gene was not altered. Exposures to chloroform at concentrations of 0.5%–2% (v/v) resulted in hypermethylation of the p53 protein in rat …
WebDec 2, 2024 · Chloroform determinations in rat blood after one year indicated that chloroform was significantly higher than control in the 100 and 1000 mg/l. ClO2 groups. However, no significant values were observed in the 1 or 10 mg/l. ClO2 and ClO2 metabolites groups. Industrially, chloroform is produced by heating a mixture of chlorine and either methyl chloride (CH3Cl) or methane (CH4). At 400–500 °C, a free radical halogenation occurs, converting these precursors to progressively more chlorinated compounds: CH4 + Cl2 → CH3Cl + HCl CH3Cl + Cl2 → CH2Cl2 + … See more Chloroform, or trichloromethane (often abbreviated as TCM), is an organic compound with the formula CHCl3 and a common organic solvent. It is a very volatile, colorless, strong-smelling, dense liquid produced on … See more The molecule adopts a tetrahedral molecular geometry with C3v symmetry. The chloroform molecule can be viewed as a methane molecule with three hydrogen atoms replaced with three chlorine atoms, leaving a single hydrogen atom. See more Chloroform was synthesized independently by several investigators circa 1831: • Moldenhawer, a German pharmacist from Frankfurt an der Oder, appears to have produced chloroform in 1830 by mixing chlorinated lime See more Exposure Chloroform is known to form as a by-product of water chlorination, along with a range of other See more The total global flux of chloroform through the environment is approximately 660000 tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Abiotic processes … See more In terms of scale, the most important reaction of chloroform is with hydrogen fluoride to give monochlorodifluoromethane CHCl3 + 2HF → CHClF2 + 2 HCl The reaction is … See more Some anaerobic bacteria use chloroform for their respiration, termed organohalide respiration, converting it to dichloromethane. See more
WebDifferent Pathways of Chloroform Metabolism Abstract. Chloroform metabolism can occur in liver, under physiological pO 2 conditions, with and without participation... …
WebChloroform metabolism is both organ-specific and sex-specific. Chloroform is metabolized by microsomes from the renal cortex of male mice but not by those from …
WebSep 30, 1999 · CYP2E1 is the predominant enzyme involved in the metabolism of chloroform in both rodent and human tissues. There is a consistent, tissue-, species-, … if he walked into my life grammyWebApr 10, 2024 · DT-109 regulates FA degradation, GSH formation, and microbial BA metabolism ... Next, the supernatant was transferred to a new microtube containing 0.3 mL chloroform/isoamyl alcohol (24:1) per 1.5 mL of Trizol reagent. After centrifugation at 12,000 g for 10 min at 4°C, the aqueous phase was transferred to a new microtube, and … if he walked into my life eydie gormeWebChloroform is well absorbed, metabolized, and eliminated by mammals after oral, inhalation, or dermal exposure and widely distributed in the entire organism, via blood … if he\u0027s so smart how come he\u0027s dead simpsonsWebChloroform is metabolised in humans and animals by oxidative or reductive cytochrome P450 dependent pathways. It has been suggested that chloroform … is sofia vergara a us citizenWebBiodegradation studies were conducted for major organic solvents such as methanol, ethanol, isopropanol, acetone, acetonitrile, toluene, chloroform, and carbon tetrachloride commonly used in pharmaceutical industries. Various microbial isolates were enriched and screened for their biodegradation pot … is sofia the first hispanicWebChloroform is toxic to the bone marrow and may also cause a deficiency of plasma prothrombin and fibrinogen. A full blood count should be performed; monitor plamsa … if he\\u0027s so great why do i feel so badWebChloroform (CF) is largely produced by both anthropogenic and natural sources. It is detected in ground and surface water sources and it represents the most abundant halocarbon in the atmosphere. Microbial CF degradation occurs under both aerobic and anaerobic conditions. if he walked into my life today