Cholesterinester hydrolase
WebDec 1, 2000 · Metrics. Disruption of the gene encoding the cholesterol modifying enzyme ACAT2 in mice leads to a reduced capacity to absorb cholesterol and resistance to diet-induced hypercholesterolemia. This ... Webcho·lin·es·ter·ase. ( kō'lin-es'ter-ās ), One of a family of enzymes capable of catalyzing the hydrolysis of acylcholines and a few other compounds. In mammals, found in …
Cholesterinester hydrolase
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Webcholinesterase: [noun] an enzyme that occurs chiefly at neuromuscular junctions and promotes the hydrolysis of acetylcholine at postsynaptic receptors : acetylcholinesterase. WebApr 1, 1974 · Cholesterol esters are hydrolyzed to free cholesterol by cholesterol ester hydrolase (EC 3.1.1.13). The free cholesterol produced is oxidized by cholesterol oxidase to cholest-4-en-3-one with the simultaneous production of hydrogen peroxide, which oxidatively couples with 4-aminoantipyrine and phenol in the presence of peroxidase to …
Web胎牛血清（杂交瘤细胞专用） sp2/0 小鼠骨髓瘤细胞. 佐剂乳化器 NCEH is a serine hydrolase that contains an N-terminal transmembrane domain, a central catalytic domain and a lipid-binding domain at its C-terminus. The protein exists in three isoforms that result from differences in mRNA splicing. Transcripts encode a protein for isoform a of 448, b of 440 and c … See more Neutral cholesterol ester hydrolase 1 (NCEH) also known as arylacetamide deacetylase-like 1 (AADACL1) or KIAA1363 is an enzyme that in humans is encoded by the NCEH1 gene. NCEH is an … See more The enzymatic reaction catalyzed by NCEH is: • 2-acetyl monoalkylglycerol ether → monoalkylglycerol … See more • Autotaxin • phosphatidic acid • Lysophospholipid receptor • LPA signaling See more Evidence suggests a role for NCEH in cancer. Cancer cell lines contain unusually high levels of the protein. Reduction of the amount of NCEH1 … See more • Herman AG, Stockwell BR (Oct 2006). "Enzyme annotation with chemical tools". Chemistry & Biology. 13 (10): 1013–1014. doi:10.1016/j.chembiol.2006.10.002. PMID 17052604. • Chiang KP, Niessen S, Saghatelian A, Cravatt BF (Oct 2006). "An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling" See more
WebThe enzyme cholinesterase (EC 3.1.1.8, choline esterase; systematic name acylcholine acylhydrolase) catalyses the hydrolysis of choline-based esters: . an acylcholine + H 2 O … WebJan 1, 2013 · Cholesterol esterase (CE) is also known as cholesterol ester hydrolase. This enzyme catalyzes the following reaction: Sterol Ester --------> Sterol + Fatty Acid. …
WebThe use of five cholesterol ester hydrolases (CEH), numbered 1 to 5, for the enzymatic determination of total cholesterol of human and rat serum are compared. All CEH …
WebSep 23, 2013 · The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages. Circ Res, 107 (2010), pp. 1387-1395. View in Scopus Google Scholar [46] M. Sekiya, J. Osuga, S. Nagashima, et al. Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. christine kneer aronoff md cincinnatiWebThe more commonly used names include carboxyl ester lipase (CEL), which is based on its general reactivity with lipids containing carboxyl ester bonds; cholesterol esterase or … german astrology chartWebThe cholesterol substrate required for sustained adrenal steroidogenesis is largely derived from the endogenous stores of cholesterol esters, which are located in large lipid inclusion droplets in the cytoplasm. In isolated adrenal cells, these esters are hydrolyzed during a variety of stimuli associated with cellular cAMP production. german astronauts nameWebMar 29, 2024 · 57552 - Gene ResultNCEH1 neutral cholesterol ester hydrolase 1 [ (human)] Predicted to enable hydrolase activity. Predicted to be involved in ether lipid … christine knospe legauWebFeb 16, 2024 · Another process is CE hydrolysis, in which CEs are hydrolyzed into free cholesterols and free fatty mainly catalyzed by neutral cholesterol ester hydrolase 1 (NCEH1) and lysosomal acid lipase (LAL). NCEH1 hydrolyzes CEs in cytoplasm, whereas LAL hydrolyzes CE lysosome [ 7, 8, 9 ]. german astronauts issWebCholesterol ester hydrolase is highly specific for choles- terol and dihydrocholesterol for esterification but is also active to a lesser extent with fl-sitosterol, stigmasterol, and ergosterol. german asymmetrical planeWebCholesterol ester hydrolase inhibitors Abstract The compounds of the formula: ##STR1## in which X is ##STR2## where R.sup.7 is hydrogen, alkyl, hydroxy, alkanoyloxy, hydroxyalkyl, hydroxycarbonyl, alkoxycarbonyl, phenyl or substituted phenyl, in which the substituent is alkyl, alkoxy, halo, nitro, cyano, haloalkyl, perhaloalkyl or ... christine knorr nyack