Web3 de abr. de 2024 · Results. Hepatocyte-specific HIF-2α knockout had no effect on the growth, liver function, glucose or lipid metabolism in mice. CCl 4-treated KO and WT mice had a similar pattern of injury and inflammatory cell infiltration in the liver.Quantification of Masson staining, α-smooth muscle actin (α-SMA) immunohistochemistry, and the … Web1 de jun. de 2024 · New Therapeutic Targets in Cardiovascular Diseases (Mar 2024) Immunometabolism (Jan 2024) Circadian Rhythm (Oct 2024) View all review series ... Viewpoint Collections In-Press Preview Commentaries Research letters Letters to the editor Editorials Viewpoint Top read articles Clinical Medicine JCI This Month Current issue …
FDA Approves Merck’s Hypoxia-Inducible Factor-2 Alpha (HIF-2α ...
WebInhibition of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) can lead to increased red blood cell production and improved oxygen delivery to tissues. The discovery of HIF has laid the foundation to help understand the central role of oxygen sensing in many diseases, including anemia due to CKD. Web11 de jun. de 2024 · Conflict of interest: The author is a founder of and holds equity in HIF Therapeutics, Inc., which is focused on developing HIF inhibitors for the treatment of cancer and blinding eye diseases. This arrangement has been reviewed and approved by the Johns Hopkins University in accordance with its conflict-of-interest policies. christmas coaster patterns for plastic canvas
JCI - HIF-1α and HIF-2α redundantly promote retinal ...
Web3 de nov. de 2016 · Here we show that a small molecule (PT2399) that directly inhibits HIF-2α causes tumour regression in preclinical mouse models of primary and metastatic … WebHIF activation is involved in tumour growth and metastasis (see Wicks & Semenza, 2024), and it is therefore a concern that if drugs that potentiate the action of HIF-1α and HIF-2α are used in individuals with developing cancers, these drugs will potentiate the proliferation and metastasis of cancer cells particularly as low expression of the HIF-PH enzymes in … Web21 de mai. de 2024 · Peloton Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on translating novel scientific insights into first -in ... HIF-2α was … christmas d\\u0026d one shot