2024 Human psap protein

Human psap protein

Author: zyne

August undefined, 2024

WebTransmembrane Protein; Recombinant Human Prostatic acid phosphatase(ACP3)-VLPs; Recombinant Human Prostatic acid phosphatase(ACP3)-VLPs. Code: CSB-MP001181HU(F2) Size: $6678: Image: CSB-MP001181HU(F2) is detected by Mouse anti-6*His monoclonal antibody. Web23 Sep 2024 · Using new technologies to explore the entire genome of a human neuron, a research team has identified the PSAP gene as important for the cell’s survival and …

Prosaposin facilitates sortilin-independent lysosomal trafficking of ...

Web19 May 2010 · Sap C is a member of a family of four small lysosomal glycoproteins (Saps A, B, C and D), all derived by proteolytic processing from a common precursor protein, prosaposin (PSAP), encoded by the PSAP gene on chromosome 10. Saps are essential cofactors for the lysosomal degradation of sphingolipids (SLs). WebProsaposin is the precursor of four smaller proteins called saposin A, B, C, and D, which are produced when prosaposin is broken up (cleaved). The individual saposins are found in cellular structures called lysosomes, which are the cell's recycling centers. The saposins help lysosomal enzymes break down fatty substances called sphingolipids. darell o cox

A Guide to Macrophage Markers - Biocompare

Web12 Apr 2024 · In both H4 cells and human neurons, protein analysis revealed no expression of MR whilst mannose-6-phosphate ... a complete knock-out of Psap (PS-) substituted by a low-expressing mouse Psap ... WebThe Pathology section contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analysis based on mRNA expression levels of human … WebZfp189, which encodes a previously unstudied zinc finger protein, is the highest-ranked key driver gene in the network, and overexpression of Zfp189 in prefrontal cortical neurons preferentially ... darell pierce

Mouse Gene Psap (ENSMUST00000179238.7) from GENCODE …

PSAP gene found important for a neuron’s survival

WebPSAP (prosaposin) is a nonenzymic sphingolipid activator protein. It encodes the precursor of four sphingolipid activator proteins. It is expressed in the extracellular space. PSAP exisits as a fully glycosylated (70kDa) form in the extracellular space. Web18 Apr 2024 · In these assays, Protein A shed from the beads, then bound to (and was eluted from) an immunoaffinity matrix designed to capture AD-related proteins. The … darell murphyWebPSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 … darell no me hablen

"WebPSAP: Prosaposin; Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the … " - Human psap protein

Human psap protein

PSAP protein (human) - STRING interaction network

Web9 Apr 2024 · Products > Proteins/Peptides > Human > Full-length - Product List - Abnova. Innovate through Integrated Solutions Home; Contact Us; ... Protein+Antibody+Mass; ACTN4 FISH Probe; CytoQuest™ CR; Web21 Mar 2024 · Molecular function for PSAP Gene according to UniProtKB/Swiss-Prot Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta …

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WebBuy 5-Chloro-2-phenylsulfanyl-phenylamine (CAS No. 4235-20-5) from Smolecule. Molecular Formula: C12H10ClNS. Molecular Weight: 235.73 g/mol. 5-Chloro-2-phenylsulfanyl-phenylamine, also known as 5-Cl-2-PSAP, is a chemical compound that has gained significant interest in the scientific community. WebProduct Pages: Species: Gene Names: Gene Aliases: RefSeq Accessions: SNP IDs (if applicable): Mature Names (if applicable): Human: surfactant protein A1: COLEC4;PSAP ...

WebProsaposin (sphingolipid activator protein 1) antibody; prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) antibody; Prosaposin antibody; Protein A … WebThe recombinant human PSAP protein is a fusion protein consists of the human PSAP protein (311-391aa) partnered with the N-terminal 6xHis tag. It was produced in the yeast. This recombinant PSAP protein's purity is greater than 90% determined by SDS-PAGE. After electrophoresis, there is a 12 kDa protein band presented on the gel.

WebTwo nonstructural proteins, NS3 and NS3A, have been implicated in this process. Here we show that both proteins bind to human Tsg101 and its ortholog from Drosophila melanogaster with similar strengths in vitro. This interaction is mediated by a conserved PSAP motif in NS3 and appears to play a role in virus release. WebRecombinant Human PSAP/Prosaposin Protein (Met1-Asn524) 16224-H08H with a fusion His Tag, is expressed in HEK293 Cells. With high purity, high biological activity, high …

Web10 Mar 2024 · Psap surfaced as a key-regulating gene. This gene encodes prosaposin, a highly conserved lysosomal protein involved in glycosphingolipid metabolism. As its role in atherosclerosis is unknown, we set out to study how prosaposin mediates inflammation in monocytes and macrophages.

Web27 Mar 2024 · The hypothesis that hyperactive myelin lipid catabolism is a driver of gliosis and neurodegeneration in FTD-GRN is supported, and the data provides important biochemical evidence supporting the use of MRI measures of white matter integrity in the diagnosis and management of FTD. Heterozygous mutations in the GRN gene and … darell refeWebProstatic acid phosphatase ( PAP ), also prostatic specific acid phosphatase ( PSAP ), is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer. darell primary richmondWebDescription: Mus musculus prosaposin (Psap), transcript variant 2, mRNA. (from RefSeq NM_011179) RefSeq Summary (NM_001146120): This gene encodes a multifunctional glycoprotein that plays a role in the intracellular metabolism of various sphingolipids or secreted into the plasma, milk or cerebrospinal fluid. The encoded protein undergoes … darell primary school term datesWeb14 Sep 2015 · PGRN is a resident lysosomal protein and trafficked to the lysosome via two independent pathways, directly by the sortilin receptor (13) or indirectly by binding to the soluble lysosomal... darell prohibidoWebPsap Name prosaposin Synonyms SGP-1 Feature Type protein coding gene IDs MGI:97783 NCBI Gene: 19156 Alliance gene page Transcription Start Sites 69 TSS Location & Maps more Sequence Map Chr10:60113449-60138376 bp, + strand From Ensembl annotation of GRCm39 Genetic Map Chromosome 10, 30.02 cM Strain Comparison … darell reedWeb22 Oct 2024 · The PSAP gene encodes prosaposin, a precursor of several small nonenzymatic glycoproteins termed 'sphingolipid activator proteins' (SAPs) that assist in the lysosomal hydrolysis of sphingolipids (O'Brien and Kishimoto, 1991). darell shafferWeb30 Dec 2024 · Pulmonary hypertension is a debilitating and progressive disease that includes 5 main subgroups. The only potentially curable subgroup is chronic thromboembolic pulmonary hypertension (CTEPH). 1 CTEPH is a form of precapillary pulmonary hypertension that occurs with the persistence of pulmonary thromboemboli, eventually … darell richards