WebFeb 20, 2024 · Klotho is a known anti-inflammatory protein that also contains anti-aging properties. In this two-part series, we will explore what klotho is, how it might impact inflammatory brain diseases,... WebAug 29, 2024 · Abramovitz et al. analyzed the effect of klotho administration on the sensitivity of pancreatic cancer cell lines to 5-fluorouracil and gemcitabine, chemotherapeutic drugs commonly used for the ...
The Klotho proteins in health and disease - PubMed
WebOct 18, 2024 · Klotho is actually a transmembrane protein which means that it sits in the cell wall. Most of Klotho exists outside of the cell, but can be chopped off and released into the blood, urine, and cerebrospinal fluid. These different forms of Klotho all … WebKlotho: A possible mechanism of action of SGLT2 inhibitors preventing episodes of acute kidney injury and cardiorenal complications of diabetes. Diabetes and cardiorenal … bsss result
The Effect of Klotho Treatment on Atherogenesis, Blood ... - PubMed
WebJul 12, 2024 · Several traditional medicines and/or nutraceuticals increased Klotho in rodents, including astaxanthin, curcumin, ginseng, ligustilide and resveratrol. Notably, exercise and sport activity increased Klotho. This review addresses molecular, physiological and therapeutic aspects of Klotho. WebNov 17, 2024 · Klotho (α-Klotho) is located on Chromosome 13, and has been described as an anti-aging gene. It has two major isoforms, a 135 kDa transmembrane protein that serves as an obligatory co-receptor for FGF23, and a 70 kDa secreted form. The transmembrane … WebThe Klotho promoter gene is generally hypermethylated in cancer, and overexpression or supplementation of Klotho has been found to inhibit tumor growth in various animal models. This review focuses on the protective effects of soluble Klotho in inhibiting renal fibrosis and fibrosis in distant organs secondary to renal Klotho deficiency. bsss sign in