WebJun 30, 2024 · MDR in HCC cells is mainly associated with two classical families of membrane transporters: (1) ATP-binding cassette (ABC) transporter superfamily, … Web16 hours ago · Concentrations of cDDP, ascorbate-cDDP and GSH-cDDP adducts were relatively constant in sensitive cells but GSH-cDDP decreased in resistant cells at a rate of …
Multidrug Resistance in Hepatocellular Carcinoma
WebFeb 11, 2024 · Five different mechanisms have been described on how tumor cells acquire drug resistance: (1)—reduction of drug uptake, (2)—alteration of the drug target, (3)—induction of drug-detoxifying mechanisms, (4)—repair of drug-induced damage, and (5)—insensitivity to drug-induced cell death [ 14] ( Figure 1 ). WebMar 20, 2024 · We have provided a comprehensive summary of the various strategies adopted by HCC cells, extending from apoptosis evasion, autophagy activation, drug expulsion to epigenetic transformation as modes of therapy resistance. The role of stem cells in imparting chemoresistance is also discussed. paragon bank memphis careers
Mechanism of lncRNAs in chemotherapeutic resistance of
WebFeb 13, 2024 · It is necessary to study the mechanism of kinase inhibitor resistance and explore possible solutions to overcome this resistance to improve clinical benefits. In this … Web16 hours ago · Concentrations of cDDP, ascorbate-cDDP and GSH-cDDP adducts were relatively constant in sensitive cells but GSH-cDDP decreased in resistant cells at a rate of 7.8+1.2×10-2 min-1. These results provide insights into the kinetics of cDDP and GSH efflux from RIF cells as well as constrain models of cisplatinum metabolism and resistance. WebThe aim of this study is to explore the mechanism of sorafenib resistance attributed to CSCs. The expression of CSC markers in HCC cell lines was investigated and compared before and after sorafenib treatment in vitro. In a xenograft mouse model, HCC cells were injected subcutaneously into both sides of the same nude mouse. paragon bank memphis facebook