Mouse atf4
NettetActivating transcription factor 4 (ATF4) is a critical transcription factor for osteoblast (OBL) function and bone formation; however, a direct role in osteoclasts (OCLs) has not been … We previously reported that activation of MYC leads to phosphorylation of PERK and eIF2α11. To test whether MYC activation also induces ATF4, we analysed ATF4 expression following MYC induction in DLD-1 human colon adenocarcinoma cells and mouse embryonic fibroblasts (MEFs) stably expressing a tamoxifen … Se mer Amino acid deficiency leads to accumulation of uncharged tRNAs, which in turn bind to GCN2, resulting in its autophosphorylation … Se mer Since ATF4 is critical for survival following MYC activation (Fig. 1c–e), we performed chromatin immunoprecipitation with sequencing (ChIP–seq) in DLD-1 MycER cells with or without … Se mer
Mouse atf4
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NettetCatalog #. AM16708. Standard 5 nmol. Purification: HPLC In-Vivo Ready Standard. Size: 5 nmol 20 nmol 20 nmol 20 nmol 20 nmol 40 nmol 40 nmol 100 nmol 250 nmol 250 nmol 1 umol 10 umol. Availability: Inventoried. Nettet7. apr. 2024 · Activating transcription factor 4 (ATF4) is a translationally activated protein that plays a role in cellular adaptation to several stresses. Because these stresses are associated with various ...
NettetMice homozygous for one knock-out allele exhibit postnatal lethality, abnormal lens development, and reduced male fertility. Mice homozygous for a different knock-out … Nettet4. apr. 2024 · ATF4 deficiency reduced the rate of birth of SOD1-G86R transgenic ALS-model mice. ATF4 plays a critical role in regulating hepatic lipid metabolism in …
Nettet17. jun. 2024 · An activating transcription factor (ATF)-binding site is a promoter element present in a wide variety of viral and cellular genes, including E1A-inducible adenoviral genes and cAMP-inducible cellular genes. Hai et al. (1989) identified cDNAs encoding 8 different human ATF consensus-binding proteins, including a partial cDNA … Nettet4. apr. 2024 · Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. ATF4-mediated transcriptional regulation protects against beta …
Nettet2. jun. 2024 · Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic mechanism that couples ...
NettetWestern Blot analysis of Rat Brain showing detection of ~39 kDa (isoform 2) ATF4 protein using Mouse Anti-ATF4 Monoclonal Antibody, Clone S360A-24 (SMC-447). Lane 1: Molecular Weight Ladder (MW). Lane 2: Rat Brain. Load: 15 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-ATF4 Monoclonal Antibody (SMC-447) at 1:1000 … nurses in netherlandsNettet22. mar. 2024 · Here, a streptozotocin-induced DN C57BL/6 mouse model was used to investigate the effects of puerarin on the modulation of autophagy under conditions associated with ... LC3II, and Atg5, and downregulated p62 expression. In addition, the levels of PERK, eIF2α, and ATF4 were reduced in the DN model, which was partially, … nitro 5 sound not workingNettetWe hypothesized that increased activity of ATF4, the mammalian equivalent of yeast GCN4, might be characteristic of mutations that extend mouse life span. Fibroblasts from the skin of two such mutants (Snell dwarf and PAPP-A knockout) were found to have higher levels of ATF4 protein and expression of several ATF4 target genes in … nurses in new zealandNettet19. nov. 2015 · (D) Percentage of input of the ATF4 antibody using mouse FL cells based on the chromatin immunoprecipitation (ChIP) assay. Primers were designed to amplify … nurses in short supplyNettet18. aug. 2016 · The PERK pathway is the most important and also includes the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) and ATF4. In this … nurses in pearl harborNettetThank you for your interest in Mouse Anti-ATF4 Monoclonal Antibody (NS360A-24), Conjugated. Please provide us with your contact information and your local representative will contact you with a customized quote. Where appropriate, they can also assist you with a(n): Estimated delivery time for your area; nitro 5 wifi driverNettet25. feb. 2024 · We next examined if any of the ISR kinases is required for the GSK-J4-triggered ATF4 induction with the use of mouse embryonic fibroblast cell lines (MEFs) … nitro 7 an715-51 screen hz