Pitavastatin pbpk
WebPitavastatin is used along with a healthy diet and exercise to reduce bad cholesterol and increase the amount of good cholesterol in the blood. It belongs to a class of medicines … WebThe final pitavastatin PBPK model was verified by simu-lating the single oral dose of 4 mg pitavastatin [23], the exposure changes of pitavastatin in different genotypes of SLCO1B1, or in the presence of OATP1B1 inhibitors as described below. The simulated results were compared to the clinical observations to determine the model performance.
Pitavastatin pbpk
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WebAug 30, 2024 · Purpose: This study aimed to examine OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3) on the pharmacokinetics of valsartan. Twenty-five subjects were genotyped for 16 single-nucleotide polymorphisms of the SLCO1B1 and SLCO1B3 genes. Methods: After a single dose of 160 mg of valsartan was orally administered to healthy male volunteers, … WebNov 17, 2016 · Method Pitavastatin and atorvastatin PBPK models were developed using in vitro and human pharmacokinetic data in a population-based PBPK software (SimCYP®) …
WebAug 3, 2024 · Briefly, minimal PBPK distribution models were used for both CYP2C8 substrates rosiglitazone and pioglitazone assuming rapid-equilibrium between blood and the liver compartments. 43, 44 For the OATP1B substrate pitavastatin and the OATP1B/CYP2C8 dual substrate repaglinide, full PBPK distribution models 45 were … WebDec 1, 2024 · Organic anion–transporting polypeptide (OATP) 1B1/3–mediated drug-drug interaction (DDI) potential is evaluated in vivo with rosuvastatin (RST) as a probe substrate in clinical studies. We calibrated our assay with RST and estradiol 17- β -D-glucuronide (E217 β G)/cholecystokinin-8 (CCK8) as in vitro probes for qualitative and quantitative …
WebJan 1, 2013 · Pitavastatin, a 3-hydroxyl-3-methylglutaryl-coenzyme A reductase inhibitor is distributed to the liver, a target organ of action and excreted mainly into the bile. To investigate the impact of influx (OATP1B1) and efflux (MRP2, BCRP) transporter alleles on its disposition, ... WebDec 1, 2024 · Organic anion–transporting polypeptide (OATP) 1B1/3–mediated drug-drug interaction (DDI) potential is evaluated in vivo with rosuvastatin (RST) as a probe …
WebMay 1, 2016 · A simulation was conducted to design this study using the PBPK models of CysA and pitavastatin constructed previously. 17 CysA doses used in the simulation were 20, 35, 50, 75, and 100 mg, and the ...
WebJun 1, 2015 · The aim of this w ork was to construct a nd re fi ne a PBPK model of irbe sartan taking into account its ac tive uptake via OA TP1B1/B3 in or der to predic t more accurat ely its pharmac okinetic ... build credit card annual feeWebOct 26, 2024 · Europe PMC is an archive of life sciences journal literature. build credit by saving moneyWebMar 6, 2024 · The clinical pharmacokinetic data following an oral 1 mg pitavastatin dose in healthy volunteers 2 were used to validate the … build credit card comenityWebNational Center for Biotechnology Information crossword clue hang aroundWebNov 17, 2016 · Pitavastatin and atorvastatin PBPK models were developed using in vitro and human pharmacokinetic data in a population-based PBPK software … crossword clue hammered instrumentWebMay 6, 2024 · Supplementary Table 5 - OATP1B1/3 values used as inputs in other models of pravastatin, rosuvastatin, repaglinide, and pitavastatin using the Simcyp simulator. … crossword clue half up frontWebA PBPK simulation study of selective substrates of CYP2C8 (rosiglitazone), OATP1B1 (pitavastatin), and of both proteins (repaglinide) highlighted that the activity of hepatic OATP1B may be reduced ... crossword clue handle clumsily