SpletTPMT is the primary metabolic route for inactivation of thiopurine drugs in the bone marrow. When TPMT activity is low, it is predicted that proportionately more 6-mercaptopurine can be converted into the cytotoxic 6-thioguanine nucleotides that accumulate in the bone marrow causing excessive toxicity. Splet21. okt. 2024 · Ari et al. and Hadda et al. also advocated screening for TPMT activity before commencing azathioprine therapy to identify patients with an increased risk of developing severe myelosuppression. [7-9] As suggested by the previous studies, a study from China showed that TPMT polymorphism is relatively rare in the Asian population.
Thiopurine S-Methyltransferase (TPMT)
Splet21. avg. 2024 · Azathioprine is a purine analogue and prodrug of mercaptopurine that is used as an immunosuppressive agent in organ transplantation to prevent rejection and in autoimmune diseases as a corticosteroid sparing agent. Azathioprine is associated with minor, usually transient and asymptomatic elevations in serum aminotransferase levels … Splet11. avg. 2024 · The response to 6-mercaptopurine (6-MP) can be altered by genetic polymorphisms in genes encoding drug-metabolizing enzymes and drug transporters. The purpose of this study was to investigate the association between genetic polymorphisms of drug-metabolizing enzymes (TPMT 719A > G (*3C), ITPA 94C > A and ITPA 123G > A) … praxes amherst ns
Thiopurine S-methyltransferase (TPMT) assessment prior to …
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